Clinical Trials
The fundamental goal of our work is to improve outcomes for the patients we serve. This makes the clinical translation of our therapies the most important step in the process. We collaborate with expert clinical trialists to develop clinical trials rooted in our preclinical work. The goal of these studies is to test these agents in a rigorous fashion and at the same time gain insight into the fundamental biology of the disease. SARC037 is the realization of this approach. This study was developed in collaboration with national experts in sarcoma and provides the basis for future clinical studies of this compound and analogs such as lurbinectedin.
Importantly this study also features excellent key collaborations with translational scientists locally at CHOP/Penn and across the country to allow us to perform 18F-FLT PET Imaging, single cell and bulk transcriptional analysis, model building, translocation typing and mutational profiling of individual patients.
Future directions, goals and current projects: We have a number of projects in various stages of clinical translation. All of our studies in the lab are performed with the clinic as the goal with careful consideration of these principles at a very early stage in project development.