Our Research

The goal of the Grohar lab is to develop effective targeted therapies for pediatric solid tumors. We believe in an integrated bench-to-bedside and back again approach that utilizes mechanistic pharmacology as a bridge between discovery science and the clinic. Our lab utilizes unbiased screens to identify novel targeted agents and drug combinations. We then focus on the mechanism of target suppression to identify novel combination therapies and translate the observations to the in vivo setting. Finally, we design clinical trials with pharmacokinetic/pharmacodynamic biomarkers of target suppression and correlative biology that further  informs our preclinical studies.